COMPARATIVE ANALYSIS OF CLINICAL AND LABORATORY FEATURES OF ACUTE VIRAL HEPATITIS E AND A IN ADULTS IN THE SOUTHERN REGION OF THE KYRGYZ REPUBLIC

The paper presents a comparative analysis of clinical and laboratory features of acute viral hepatitis E (AVHE) and A (AVHA) in adults.A retrospective study was conducted on 134 patients diagnosed with AVHE and 126 with AVHA who were hospitalized in the infectious disease departments of the Osh Regional United Clinical Hospital, Jalal-Abad Regional Clinical Hospital, and Batken Regional Clinical Hospital in the southern regions of the Kyrgyz Republic.A comparative analysis of clinical and laboratory features revealed significant differences between AVHE and AVHA in adult patients.AVHE mainly affected older age groups and was characterized by a more severe course, prolonged prodromal phase, high incidence of severe jaundice, and more pronounced cholestasis compared with AVHA.Male patients were more likely to be affected by forging.The results of laboratory tests in patients with AVHE also indicated more severe liver dysfunction, as shown by higher levels of bilirubin, alanine transaminase, and alkaline phosphatase, and a decrease in albumin concentration.These findings were in contrast to those observed in acute viral hepatitis A. Thus, the results emphasize the need for increased clinical vigilance against hepatitis E in endemic areas and optimization of diagnostic approaches, particularly among adult patients.