Mendelian Randomization and Transcriptomics Analysis Reveal Potential Relationships Between Lipids, Immune Cells and PCOS
Our results provide genetic and transcriptomic evidence substantiating the potential relationship between lipids, immune cells, and PCOS. CD4+ T cells might be key mediators in the causal association between lipids and PCOS. Comprehending this relationship could enhance treatment and prevention strategies for PCOS through the comprehensive management of lipid irregularities. Further experimental studies are required to elucidate the detailed mechanisms involved in this relationship.
Authors
- Yuanyuan Zhao (ORCID: https://orcid.org/0000-0003-0440-1170)
- Xie Yafei
- Jiali Zhang (ORCID: https://orcid.org/0000-0002-4837-8278)
- Zelin Zhang (ORCID: https://orcid.org/0000-0002-8065-0059)
- Qiaozhi Yin
Institutions
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- International Journal of Women s Health
- Published
- 2025-08-01
- DOI
- https://doi.org/10.2147/ijwh.s534136
- Primary Topic
- Cholesterol and Lipid Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chengdu Science and Technology Bureau