Patterns of HER2 Expression in Metastatic Prostate and Urothelial Cancers: Implications for HER2-Targeted Therapies
This study demonstrates that HER2 is rarely overexpressed in metastatic prostate cancer but is more common and consistent in urothelial carcinoma. These findings highlight the need for HER2 testing in urothelial cancer and suggest that HER2-targeted therapies in prostate cancer will require careful patient selection.
Authors
- Andrew Caleb Hsieh (ORCID: https://orcid.org/0000-0002-0897-1050)
- Maria Tretiakova (ORCID: https://orcid.org/0000-0002-0819-9638)
- Jessica E. Hawley (ORCID: https://orcid.org/0000-0003-1720-5654)
- Colm M. Morrissey (ORCID: https://orcid.org/0000-0003-1906-5333)
- Michael Thomas Schweizer (ORCID: https://orcid.org/0000-0002-5510-0661)
- Hung‐Ming Lam (ORCID: https://orcid.org/0000-0001-8921-6091)
- Radhika A. Patel (ORCID: https://orcid.org/0009-0008-4889-6818)
- Farinaz Shokri
- Erolcan Sayar (ORCID: https://orcid.org/0000-0002-3922-5683)
- Samantha L. Schuster (ORCID: https://orcid.org/0000-0003-4051-5802)
- Petros D. Grivas (ORCID: https://orcid.org/0000-0003-3965-3394)
- Meagan Chambers (ORCID: https://orcid.org/0000-0002-8741-0509)
- Lawrence D. True (ORCID: https://orcid.org/0000-0002-8621-9569)
- Gavin Ha (ORCID: https://orcid.org/0000-0001-7578-7272)
- Roman Gulati (ORCID: https://orcid.org/0000-0002-7592-6567)
- Heather H. Cheng (ORCID: https://orcid.org/0000-0002-1365-0702)
- Bruce Montgomery (ORCID: https://orcid.org/0000-0003-4459-0295)
- Funda Vakar‐Lopez
- Michael C. Haffner (ORCID: https://orcid.org/0000-0003-0809-6425)
- Peter S. Nelson (ORCID: https://orcid.org/0000-0002-5451-5726)
- Ruben Raychaudhuri (ORCID: https://orcid.org/0000-0001-6587-4954)
- Ilsa M. Coleman (ORCID: https://orcid.org/0000-0002-1483-7202)
- Jonathan Lawrence Wright (ORCID: https://orcid.org/0000-0002-8447-8209)
- Evan Y. Yu (ORCID: https://orcid.org/0000-0002-1510-8044)
- Pushpa Itagi
- Sonali Arora (ORCID: https://orcid.org/0000-0002-6661-3024)
- Mohamed Adil (ORCID: https://orcid.org/0000-0003-1787-644X)
- Thomas Persse (ORCID: https://orcid.org/0009-0000-3209-592X)
- Hyun Jung Lee (ORCID: https://orcid.org/0000-0002-2995-6060)
- Helen Richards (ORCID: https://orcid.org/0009-0008-4328-488X)
Institutions
- University of Washington (US)
- Harborview Medical Center (US)
- Fred Hutch Cancer Center (US)
- Cancer Consortium (US)
- Stanford Medicine (US)
- University of Washington Applied Physics Laboratory (US)
- Pusan National University Yangsan Hospital (KR)
- Pusan National University (KR)
- Seattle University (US)
- Stanford University (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1158/2767-9764.crc-25-0069
- Citations
- 3
- Primary Topic
- HER2/EGFR in Cancer Research
- Type
- article
- Field-Weighted Citation Impact
- 3.14