Association of SCN1A Gene Polymorphisms with Sodium Valproate Resistance in Pediatric Epilepsy: A Retrospective Case-Control Study
Mutation in the SCN1A gene, specifically rs166859148, rs166894396, rs166848482, rs166915162, rs166870333-335, may contribute to resistance to sodium valproate in pediatric epilepsy. Mutations in rs166915162 and rs166870333-335 were associated with reduced plasma levels of sodium valproate, while the rs166870333-335 mutation is linked to generalized seizure types in patients with drug-resistant epilepsy.
Authors
- Tingting Geng (ORCID: https://orcid.org/0000-0003-2309-7637)
- Na Deng
- Huiyu Wang (ORCID: https://orcid.org/0000-0001-5115-5502)
Institutions
- Hubei University of Medicine (CN)
Publication Details
- Journal
- Neuropsychiatric Disease and Treatment
- Published
- 2025-08-01
- DOI
- https://doi.org/10.2147/ndt.s529263
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00