Genetic Factors Contributing to Alzheimer's Disease and FTLD

Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD) are two of the most prevalent neurodegenerative disorders, characterized by progressive cognitive decline and behavioral impairment. AD is the leading cause of dementia globally, while FTLD is the primary cause of early-onset dementia, particularly in individuals under 65. Despite clinical overlaps, these diseases differ in their pathological hallmarks, genetic underpinnings, and molecular mechanisms. This review aims to provide a brief overview of the genetic factors of AD and FTLD, highlighting their distinct pathogenesis in the progression of neurodegenerative diseases.