Giant Breast Myofibroblastoma: A Rare Case of Benign Breast Tumor in a Postmenopausal Woman

<b>Introduction:</b> Breast myofibroblastoma (MFB) is a relatively rare benign tumor that mimics the clinical presentation of malignant tumors of the breast. It has various morphologic variants that can be accurately diagnosed based on histopathology and immunohistochemistry staining. We report a case of MFB in a menopausal woman for pertinent clinical consideration and management. <b>Case Presentation:</b> We report a case of a 57-year-old Tanzanian woman, who presented with a huge right breast mass for 1 year. Initial radiological findings were inconclusive, however, the tissue specimen for histology and immunohistochemical (IHC) confirmed the diagnosis. A simple mastectomy was thereafter performed as a curative therapy. <b>Conclusion:</b> This case presentation underscores the importance of considering MFB as a potential differential for breast tumors especially in menopausal women. Tissue biopsy for histopathology and IHC staining form the cornerstone for accurate diagnosis and appropriate management.