Research Progress on SIRT6 in Pulmonary Diseases: A Comprehensive Review from Bench to Bedside

本文全面综述了SIRT6在肺部疾病中的研究进展，涵盖基础理论、流行病学、病理机制、诊断、治疗等多个方面。在基础理论部分，阐述了SIRT6的分子结构与功能及其在肺部疾病中的生物学作用和相关信号通路。流行病学研究分析了SIRT6表达水平与肺部疾病的关联、不同人群中的发病率及遗传易感性。病理机制方面，探讨了SIRT6在肺纤维化、慢性阻塞性肺疾病和肺癌发展中的作用。诊断应用上，评估了SIRT6作为生物标志物的潜力、相关诊断技术现状及早期检测前景。治疗策略包括SIRT6靶向治疗进展、激活剂的临床试验及与现有治疗方法的联合应用。同时，讨论了SIRT6研究中的争议与挑战，并对未来研究方向进行了展望。这些研究为深入理解肺部疾病的发病机制及开发基于SIRT6的治疗策略提供了重要参考。This comprehensive review systematically summarizes research advances on SIRT6 in pulmonary diseases, encompassing fundamental theories, epidemiological findings, pathological mechanisms, diagnostic approaches, and therapeutic strategies. The theoretical foundations section elucidates SIRT6’s molecular structure and functions, along with its biological roles and associated signaling pathways in pulmonary pathologies. Epidemiological investigations analyze correlations between SIRT6 expression levels and pulmonary diseases, disease incidence across populations, and genetic susceptibility factors. Regarding pathological mechanisms, the review examines SIRT6’s involvement in pulmonary fibrosis, chronic obstructive pulmonary disease (COPD), and lung cancer progression. Diagnostic applications evaluate SIRT6’s potential as a biomarker, current diagnostic technologies, and prospects for early detection. Therapeutic approaches include recent advances in SIRT6-targeted interventions, clinical trials of activators, and combination strategies with existing treatments. The review also addresses current controversies and challenges in SIRT6 research, while proposing future research directions. These collective findings provide crucial references for understanding disease pathogenesis and developing SIRT6-based therapeutic approaches for pulmonary disorders.