Evaluation of Reactogenicity and Neutralizing Antibody Responses 6 Months Post-Vaccination with Monovalent COVID-19 Vaccine
The association between reactogenicity and long-term immunogenicity after coronavirus disease 2019 (COVID-19) vaccination remains unclear. This study investigated whether adverse reactions to ChAdOx1 nCoV-19 or BNT162b2 vaccines correlate with neutralizing antibody responses in severe acute respiratory syndrome coronavirus 2 infection-naïve healthcare workers. Blood samples were collected at three time points to measure neutralizing antibodies. Among 123 participants (ChAdOx1 nCoV-19, n=88; BNT162b2, n=35), local and systemic reactions were not significantly associated with antibody responses at six months post-vaccination for either vaccine type. No significant interactions between symptoms, time points, or age were observed. These findings suggest that adverse reactions might not predict long-term neutralizing antibody levels following COVID-19 vaccination.
Authors
- Sang‐Oh Lee (ORCID: https://orcid.org/0000-0003-1381-8787)
- So Yun Lim (ORCID: https://orcid.org/0000-0002-5647-3718)
- Ji Yeun Kim (ORCID: https://orcid.org/0000-0001-6955-6427)
- Euijin Chang (ORCID: https://orcid.org/0000-0001-7417-0318)
- Jiwon Jung (ORCID: https://orcid.org/0000-0003-4333-3270)
- Hye Hee (ORCID: https://orcid.org/0000-0002-2943-3059)
- Seongman Bae (ORCID: https://orcid.org/0000-0001-6375-3657)
- Ji‐Soo Kwon (ORCID: https://orcid.org/0000-0001-6945-6100)
- Sang‐Ho Choi (ORCID: https://orcid.org/0000-0002-4972-4531)
- Sung‐Han Kim (ORCID: https://orcid.org/0000-0002-6596-8253)
- Min Jae Kim (ORCID: https://orcid.org/0000-0002-5489-8608)
- Yang Soo Kim (ORCID: https://orcid.org/0000-0002-6785-8824)
- Yong Pil Chong (ORCID: https://orcid.org/0000-0003-1672-3185)
Institutions
- Ulsan College (KR)
- Asan Medical Center (KR)
- University of Ulsan (KR)
Publication Details
- Journal
- Infection and Chemotherapy
- Published
- 2025-01-01
- DOI
- https://doi.org/10.3947/ic.2025.0027
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Korea Health Industry Development Institute