Population‐Based Survival Analysis of Solitary Plasmacytoma of Spine in the <scp>United States</scp> From 2000 to 2020

This population-based analysis of SPBS highlights key prognostic factors for 5y OS. Increased age, higher income, and single marital status were associated with worse outcomes, while radiation therapy and greater extent of surgical procedure improved survival. Notably, radiotherapy combined with surgery showed better survival than radiation alone, challenging current national guidelines that recommend radiotherapy with or without surgery. Additionally, gross total resection demonstrated the highest overall survival among the various surgical procedures. These findings suggest that incorporating combined therapy into treatment protocols could improve outcomes and refine future guidelines.