The rs10191329 Risk Allele Is Associated With Pronounced Retinal Layer Atrophy in Multiple Sclerosis
Carriers of the rs10191329 risk allele show accelerated retinal atrophy, suggesting heightened neuroaxonal vulnerability in MS. While clinical implications are currently unclear, genetic stratification may be reasonable in clinical trials targeting neuroprotection.
Authors
- Tobias Monschein (ORCID: https://orcid.org/0000-0002-6053-4210)
- Franziska Di Pauli (ORCID: https://orcid.org/0000-0001-6183-2394)
- Harald Hegen
- Barbara Kornek (ORCID: https://orcid.org/0000-0002-1851-6967)
- Axel Schmidt (ORCID: https://orcid.org/0000-0002-9780-7243)
- Paulus Stefan Rommer (ORCID: https://orcid.org/0000-0001-5209-6647)
- Gabriel Bsteh (ORCID: https://orcid.org/0000-0002-0825-0851)
- Christiane Schmied
- Lukas Haider (ORCID: https://orcid.org/0000-0002-1556-1770)
- Berthold Pemp (ORCID: https://orcid.org/0000-0002-0569-0229)
- Markus Ponleitner (ORCID: https://orcid.org/0000-0002-3709-1845)
- Nik Krajnc (ORCID: https://orcid.org/0000-0002-4146-5870)
- Thomas Berger (ORCID: https://orcid.org/0000-0001-5626-1144)
- Karin Zebenholzer (ORCID: https://orcid.org/0000-0001-6930-019X)
- Kerstin U. Ludwig (ORCID: https://orcid.org/0000-0002-8541-2519)
- Martin Krenn (ORCID: https://orcid.org/0000-0003-3026-3082)
- Fritz Leutmezer (ORCID: https://orcid.org/0000-0001-5665-8635)
- Tobias Zrzavy (ORCID: https://orcid.org/0000-0001-8909-1591)
- Gudrun Zulehner (ORCID: https://orcid.org/0000-0003-4151-684X)
- Stefan Macher (ORCID: https://orcid.org/0000-0001-8068-1528)
- Theresa König (ORCID: https://orcid.org/0000-0002-7904-8482)
- Fabian Föttinger (ORCID: https://orcid.org/0009-0005-7970-5349)
- Ruchi Tanavade
Institutions
- Innsbruck Medical University (AT)
- Queen Mary University of London (GB)
- Universität Innsbruck (AT)
- University Hospital Bonn (DE)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1002/acn3.70157
- Citations
- 3
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.41
Funders
- Amgen
- Eli Lilly and Company
- Sanofi
- Biogen
- Teva Pharmaceutical Industries
- Alexion Pharmaceuticals
- Celgene
- European Committee for Treatment and Research in Multiple Sclerosis
- Amicus Therapeutics
- Austrian Science Fund
- Rheinische Friedrich-Wilhelms-Universität Bonn
- European Academy of Neurology
- Neuraxpharm
- MedDay Pharmaceuticals
- Cilag