Oxidative Stress and Gut Microbiota Interplay Exacerbates Periodontitis in Diabetic Mice
This study demonstrates that the interaction between oxidative stress and gut dysbiosis may form a pathogenic loop associated with the exacerbation of periodontitis in diabetic conditions. The successful outcomes of antioxidant treatment and FMT suggest multiple adjunctive therapeutic approaches for managing DP.
Authors
- Haotian Gong (ORCID: https://orcid.org/0000-0002-7398-2493)
- Xulei Yuan
- Mengjiao Zhou (ORCID: https://orcid.org/0000-0002-4446-4742)
- Jinlin Song (ORCID: https://orcid.org/0000-0002-0224-6640)
- Tingwei Zhang (ORCID: https://orcid.org/0000-0002-7916-3042)
- Lei Zhang (ORCID: https://orcid.org/0000-0001-7769-7377)
- Yuanyuan Liu (ORCID: https://orcid.org/0000-0002-7126-9782)
- Jiawei Tang (ORCID: https://orcid.org/0000-0002-3432-8392)
- Yangbo Liu (ORCID: https://orcid.org/0009-0002-3550-1633)
Institutions
- Stomatological Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal Of Clinical Periodontology
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1111/jcpe.70003
- Citations
- 3
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 4.40
Funders
- National Natural Science Foundation of China
- Chongqing Youth Science and Technology Talent Training Project
- National Key Research and Development Program of China