Numerical analysis of the acoustic pressure inside blood vessel with exposure to high-intensity focused ultrasound
This study investigates acoustic pressure distribution in blood vessels under high-intensity focused ultrasound (HIFU) for sonothrombolysis (STL). A tissue-mimicking phantom (skin, fat, muscle, blood) was modeled, and pressure was calculated using the Westervelt equation. Results show peak pressure increases with frequency (0.5-2 MHz), while attenuation intensifies with higher power, frequency, and vessel depth (10-30 mm). Frequencies above 1.1 MHz caused greater attenuation, influenced by skin (1-5 mm) and fat (2-7 mm) thicknesses. Below 1.1 MHz, consistent HIFU power yields similar clinical outcomes across patients, aiding STL treatment optimization.
Authors
- Jonghyok Ri (ORCID: https://orcid.org/0000-0003-0209-8454)
- Insong Kim
- Na Pang (ORCID: https://orcid.org/0000-0002-5434-3282)
- Vincent Ji (ORCID: https://orcid.org/0000-0003-1979-7323)
- Xiangji Yue (ORCID: https://orcid.org/0000-0002-0753-8220)
- Lisheng Xu (ORCID: https://orcid.org/0000-0001-8360-3605)
- Dingchang Zheng (ORCID: https://orcid.org/0000-0001-8077-4548)
- Li Shen
Institutions
- Hebei Medical University (CN)
- Northeastern University (US)
- Ministry of Education of the People's Republic of China (CN)
- Sun Yat-sen University (CN)
- Fudan University (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Shenzhen Institutes of Advanced Technology (CN)
- Intelligent Health (United Kingdom) (GB)
- Coventry University (GB)
- Universidad del Noreste (MX)
- Northeastern University (CN)
Publication Details
- Journal
- Computer Methods in Biomechanics & Biomedical Engineering
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1080/10255842.2025.2541896
- Primary Topic
- Ultrasound and Hyperthermia Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Liaoning Province