Discussion on the Characteristics of Acupuncture Prescriptions for Restless Leg Syndrome Based on Complex Network and Data Mining

目的：探究针灸治疗不宁腿综合征的处方规律，为临床腧穴配伍提供依据。方法：检索中国知网、万方数据知识服务平台、维普资讯中文期刊服务平台、Pubmed关于针灸治疗RLS的临床文献，根据纳入、排除标准筛选出相关文献，建立数据库。运用SPSS Modeler18.0软件进行腧穴关联规则分析，并利用Gephi0.9.7软件进行复杂网络分析针灸治疗RLS的腧穴配伍规律特点。结果：共纳入文献46篇，提取54条针灸处方，82个腧穴，总使用频次为476次。高频经脉为足太阳膀胱经，其中足三里的累积运用频次最高。足三里–三阴交、足三里–太冲–三阴交为支持度最高的穴对和穴组。通过复杂网络拓扑结构分析发现足三里、三阴交、阳陵泉、委中、太冲等20个腧穴为针灸治疗RLS的核心节点腧穴。结论：不宁腿综合征针灸处方选穴多集中在下肢，以足三阳经腧穴为主，重视特定穴，体现了针灸治疗应与病症相适应的原则。Objective: To explore the prescription rule of acupuncture and moxibustion in the treatment of restless leg syndrome, and provide the basis for clinical acupoint compatibility. Methods: Clinical literature on acupuncture for restless legs syndrome was retrieved from China Knowledge Network, Wanfang Data Knowledge Service Platform, VipInfo Chinese Journal Service Platform, and Pubmed, and relevant literature was screened according to inclusion and exclusion criteria to establish a database. SPSS Modeler18.0 software was used to analyze the association rules of acupuncture points, and Gephi0.9.7 software was used to conduct complex network analysis of acupuncture point dispensing rules in acupuncture for restless legs syndrome. Results: Finally, 46 papers meeting the criteria were screened, and a total of 54 prescriptions for acupuncture and moxibustion for migraine were extracted, involving 82 acupoints, with a total frequency of 476 acupoints. The acupoints used were mainly from the foot and sun bladder meridians, with the highest cumulative frequency of use of the Tsusanli. The association rule analysis revealed that Tsusanli-Sanyinjiao and Tsusanli-Taichong-Sanyinjiao were the most supported acupoint pairs and acupoint groups. Complex network topology analysis revealed 20 acupoints, including Tsusanli, Sanyinjiao, Yanglingquan, Weizhong, and Taichong, as the core node acupoints for acupuncture treatment of restless leg syndrome. Conclusion: Acupuncture and moxibustion and moxibustion prescriptions for restless legs syndrome mostly focus on the lower limbs, focusing on the points of the Foot Sanyang Channel, and attaching importance to specific points, which reflects the principle that acupuncture and moxibustion and moxibustion treatment should adapt to the disease.