Urinary transferrin as an early Marker of Diabetic Nephropathy

Back ground: The Diabetic Kidney Disease (DKD) prevalence is increasing, making it a major healthcare issue. Early detection of DKD is a challenging medical concern. Urinary transferrin is a glycoprotein with low molecular weight and negatively charged ionic load making it simply filtered via renal glomeruli, so its levels increase even with normal albumin creatinine ratio in diabetic nephropathy (DN). Objectives: We examined the level of urinary transferrin across instances with type 2 diabetes mellitus (T2DM) to assess its validity as early markers for diabetic nephropathy. Methods: In this cross-sectional work, we tested 200 subjects, (50 healthy control, 50 normoalbuminuric T2DM patients, 50 microalbuminuric T2DM patients and 50 macroalbuminuric T2DM patients) recruited from Internal Medicine Department, Tanta University Hospitals. Patients evaluated for urinary transferrin that had been evaluated utilising enzyme-linked immunosorbent assay (ELISA). Results: urinary transferrin was significantly increased among diabetic patients even with normal albumin creatinine ratio and their levels elevated more with more elevation of albumin creatinine ratio. Conclusion: Urinary transferrin ought to be used as early markers for DN and this will provide early diagnosis and prompt intervention in these patients.