A Critical Appraisal of Off-Label Use and Repurposing of Statins for Non-Cardiovascular Indications: A Systematic Mini-Update and Regulatory Analysis

<b>Background:</b> Statins exhibit pleiotropic anti-inflammatory, antioxidant, and immunomodulatory effects, suggesting their potential in non-cardiovascular conditions. However, evidence supporting their repurposing remains limited, and off-label prescribing policies vary globally. <b>Objective:</b> To systematically review evidence on statin repurposing in oncology and infectious diseases, and to assess Hungarian regulatory practices regarding off-label statin use. <b>Methods:</b> A systematic literature search (PubMed, Web of Science, Scopus, ScienceDirect; 2010-May 2025) was conducted using the terms "drug repositioning" OR "off-label prescription" AND "statin" NOT "cardiovascular," following PRISMA guidelines. Hungarian off-label usage data from the NNGYK (2008-2025) were also analyzed. <b>Results:</b> Out of 205 publications, 12 met the inclusion criteria-75% were oncology-focused, and 25% focused on infectious diseases. Most were preclinical (58%); only 25% offered strong clinical evidence. Applications included hematologic malignancies, solid tumors, Cryptococcus neoformans, SARS-CoV-2, and dengue virus. Mechanisms involved mevalonate pathway inhibition and modulation of host immune responses. Hungarian data revealed five approved off-label statin uses-three dermatologic and two pediatric metabolic-supported by the literature and requiring post-treatment reporting. <b>Conclusions:</b> While preclinical findings are promising, clinical validation of off-label statin use remains limited. Statins should be continued in cancer patients with cardiovascular indications, but initiation for other purposes should be trial-based. Future directions include biomarker-based personalization, regulatory harmonization, and cost-effectiveness studies.