Scopoletin and Scoparone from Viola philippica Attenuate the Virulence of Pseudomonas aeruginosa by Inhibiting Quorum Sensing-Related Genes
Scopoletin and scoparone, two previously uncharacterized coumarin derivatives from VPE, were identified as novel QSIs. They are responsible for VPE's effect on weakening QS-controlled virulence of PAO1 by inhibiting QS-related genes. This study provides a laboratory basis for using scopoletin and scoparone as promising anti-virulence candidates for adjuvant therapy against <i>P. aeruginosa</i> infection.
Authors
- Songbang Ou (ORCID: https://orcid.org/0000-0001-6817-0290)
- Cong Shen (ORCID: https://orcid.org/0000-0003-2677-3960)
- Dexiang Zheng
- Yanfen Luo
- Jianming Zeng (ORCID: https://orcid.org/0000-0002-7020-3386)
- Bin Huang (ORCID: https://orcid.org/0000-0001-8769-7979)
- Shebin Zhang
- Jieying Pu (ORCID: https://orcid.org/0000-0002-7473-6972)
- Chen Cha (ORCID: https://orcid.org/0000-0001-7275-1231)
- Weiying Chen (ORCID: https://orcid.org/0000-0002-1466-8891)
- Qian Xiao (ORCID: https://orcid.org/0009-0009-3720-0341)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Guangdong Provincial Hospital of Traditional Chinese Medicine (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Guangdong Provincial People's Hospital (CN)
Publication Details
- Journal
- Infection and Drug Resistance
- Published
- 2025-08-01
- DOI
- https://doi.org/10.2147/idr.s530778
- Primary Topic
- Biochemical and Structural Characterization
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Traditional Chinese Medicine Bureau of Guangdong Province