Use of Pyridoxal-5′-phosphate for Olanzapine-induced Tardive Dyskinesia: A Case Report

REPORTTHP 2 mg, baclofen 30 mg, and tetrabenazine 75 mg but showed negligible improvement on applying AIMS-14 points (moderate).These symptoms significantly impacted the patient's quality of life and daily functioning.Upon further evaluation and discussion with the patient, a treatment plan was developed that included the introduction of PLP, with known effects on reducing muscle stiffness and pain.The patient was instructed to take P-5-P 500 mg daily, and he reported an improvement in both neck pain and stiffness in 3 months (AIMS-11 points).The patient experienced about 70% reduction in neck discomfort and the severity of involuntary neck movements.By the end of 1 year, with an AIMS score of 5 points (mild severity index).The patient noted increased ease in performing daily activities, with fewer episodes of painful spasms.

Authors

Publication Details

Journal
The Journal of Medical Sciences
Published
2025-08-01
DOI
https://doi.org/10.5005/jp-journals-10045-00419
Primary Topic
Schizophrenia research and treatment
Type
article
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article

Use of Pyridoxal-5′-phosphate for Olanzapine-induced Tardive Dyskinesia: A Case Report

Vishnu Vardhan, Vidhyavathi Malyam, Shridhar Manakame SK, Siddharam SJ
The Journal of Medical Sciences
Schizophrenia research and treatment
article

Use of Pyridoxal-5′-phosphate for Olanzapine-induced Tardive Dyskinesia: A Case Report

Vishnu Vardhan, Vidhyavathi Malyam, Shridhar Manakame SK, Siddharam SJ
article en

Abstract

REPORTTHP 2 mg, baclofen 30 mg, and tetrabenazine 75 mg but showed negligible improvement on applying AIMS-14 points (moderate).These symptoms significantly impacted the patient's quality of life and daily functioning.Upon further evaluation and discussion with the patient, a treatment plan was developed that included the introduction of PLP, with known effects on reducing muscle stiffness and pain.The patient was instructed to take P-5-P 500 mg daily, and he reported an improvement in both neck pain and stiffness in 3 months (AIMS-11 points).The patient experienced about 70% reduction in neck discomfort and the severity of involuntary neck movements.By the end of 1 year, with an AIMS score of 5 points (mild severity index).The patient noted increased ease in performing daily activities, with fewer episodes of painful spasms.

The Journal of Medical SciencesVol. 11(1--4)
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Schizophrenia research and treatment
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