Use of Pyridoxal-5′-phosphate for Olanzapine-induced Tardive Dyskinesia: A Case Report
REPORTTHP 2 mg, baclofen 30 mg, and tetrabenazine 75 mg but showed negligible improvement on applying AIMS-14 points (moderate).These symptoms significantly impacted the patient's quality of life and daily functioning.Upon further evaluation and discussion with the patient, a treatment plan was developed that included the introduction of PLP, with known effects on reducing muscle stiffness and pain.The patient was instructed to take P-5-P 500 mg daily, and he reported an improvement in both neck pain and stiffness in 3 months (AIMS-11 points).The patient experienced about 70% reduction in neck discomfort and the severity of involuntary neck movements.By the end of 1 year, with an AIMS score of 5 points (mild severity index).The patient noted increased ease in performing daily activities, with fewer episodes of painful spasms.
Authors
- Vishnu Vardhan (ORCID: https://orcid.org/0000-0002-3780-2854)
- Vidhyavathi Malyam
- Shridhar Manakame SK
- Siddharam SJ
Publication Details
- Journal
- The Journal of Medical Sciences
- Published
- 2025-08-01
- DOI
- https://doi.org/10.5005/jp-journals-10045-00419
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00