Hydroaminoalkylation of 1,3-dienes by dual photoredox and nickel catalysis
A dual nickel/photoredox catalyzed hydroaminoalkylation of 1,3-dienes is presented. In this atom-economic and energetic protocol, the bulk industrial raw material isoprene and its derivatives are employed as allylic electrophile surrogates, which undergo a coupling with photoredox-generated α-amino alkyl radical species to produce valuable homoallylic amines efficiently. Preliminary mechanism experiments support the intervention of Ni-hydride species that undergo diene insertion to form Ni-allyl intermediates.
Authors
- Enhui Zhou
- Lei Shi (ORCID: https://orcid.org/0000-0002-2644-1168)
- Yuqing Chen (ORCID: https://orcid.org/0000-0001-9742-2661)
- Jing‐Ran Shan (ORCID: https://orcid.org/0009-0007-7968-7595)
- Heyang Xu
- Lu Qiu
- F.N. Jin (ORCID: https://orcid.org/0009-0009-7920-9838)
Institutions
- University of California, Los Angeles (US)
- Dalian University of Technology (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc03221k
- Citations
- 1
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China