Genome‐wide associations with metabolic syndrome among <scp>UK</scp> Biobank participants reporting use of second‐generation antipsychotics
Using a gene-based analysis, we identified significant gene associations with SGA-MetS that have been previously associated with obesity and metabolic traits. The PGS-BMI was associated with MetS, suggesting that a genetic predisposition to a higher BMI may increase the risk of SGA-MetS. Future research should replicate the findings in a larger dataset with more diverse populations.
Authors
- Simon Lee (ORCID: https://orcid.org/0000-0003-1874-2515)
- Melissa P. DelBello (ORCID: https://orcid.org/0000-0003-1837-4126)
- Leah C. Kottyan (ORCID: https://orcid.org/0000-0003-3979-2220)
- Lisa Joy Martin (ORCID: https://orcid.org/0000-0001-8702-9946)
- Bahram Namjou‐Khales
- Aniwaa Owusu‐Obeng
- Nihal El Rouby (ORCID: https://orcid.org/0000-0003-1652-3773)
- Michael Preuß (ORCID: https://orcid.org/0000-0001-5266-8465)
- Michael Lape
- Sara L. Van Driest (ORCID: https://orcid.org/0000-0003-2580-1405)
- Mingjian Shi (ORCID: https://orcid.org/0000-0003-1569-9822)
- Jonathan D. Mosley (ORCID: https://orcid.org/0000-0001-6421-2887)
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- National Institutes of Health (US)
- American Baptist College (US)
- St. Elizabeth Healthcare (US)
- Tennessee Department of Health (US)
- University of Cincinnati (US)
- Vanderbilt University Medical Center (US)
- University of Cincinnati Medical Center (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/phar.70041
- Citations
- 2
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 3.63
Funders
- ACCP Foundation