Role of the Phytochemicals in Cervical Cancer: Current Understanding of Pharmacological Actions and Associated Molecular Mechanisms

Natural products have been used as an important biological resource for drug discovery for the last fifty years.Cancer is one of the main causes of death globally.Patients' quality of life is negatively impacted by the severe side effects of conventional cancer treatments.Although there have been significant advancements in the field of cancer therapy, the utilization of chemotherapeutic approaches is severely limited by issues such as drug resistance, distant metastases, toxicity, and related side effects.Cervical cancer (CC) is the third most frequent malignancy in women and the fourth most dangerous disease worldwide.Research on natural products has broadened to include compounds other than conventional anticancer drugs due to their chemoprotective and chemosensitizing qualities.Examining the available scientific data on their use in the treatment of CC is the goal of this study.The terms cancer, cervical cancer, phytochemical, pharmacological, and herbal medicine were used to gather the scientific data for this review from PubMed, Scopus, Science Direct, and Google.The current review article's scientific findings outline the biological potential of phytochemicals: -mangostin, 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone (DMC), 10-gingerol (10-G), sesamol, gallic acid, punicalagin, resveratrol, indole-3-carbinol (I3C), -tocotrienol, caffeic acid, naringin, quercetin, curcumin, chrysin, plumbagin, alloimperatorin, calycopterin, engeletin, moscatilin, and chamaejasmine in medicine.The biological significance of phytochemicals for treating CC was indicated by the scientific findings presented in this review article.Additionally, this review article also discussed their different molecular mechanisms.Scientists studying the medicinal properties of herbal products will find this article's scientific content useful for the treatment of CC.