Pyodermatitis-Pyostomatitis Vegetans with Eyelid Involvement: A Rare Manifestation in a Patient with Ulcerative Colitis

This case highlights the importance of considering PDV-PSV in UC patients who developed atypical mucocutaneous manifestations, especially when standard treatment regimen for supposed infectious etiologies fail. Although uncommon, eyelid involvement should be considered as a potential manifestation of PDV-PSV. Histopathological evaluation and direct immunofluorescence study remains essential for diagnosis, especially in cases presenting with unusual manifestations. Consideration of PDV-PSV as a mucocutaneous manifestation of UC is essential to avoid misdiagnoses and prevent unnecessary treatments. While periocular involvement may be rare, the presence of typical skin and oral lesions, along with distinctive histological and immunofluorescence findings, should guide clinicians toward the correct diagnosis.