The significance of the PPARG gene in the recurrence of purulent complications after lower limb bone injury treatment

Objective. To study the effect of the PPARG gene on the course of purulent complications after lower limb bone injury treatment. Materials and methods. A prospective genetic study was conducted involving 114 patients who were treated at the N.V. Solovyov Hospital (Yaroslavl) in the period from 2018 to 2024 for purulent-inflammatory complications after lower limb injuries from 2018 to 2024. The polymorphism of the PPARG C1431T gene (rs3856806), which plays a key role in the regulation of the inflammatory response and reparative processes, was used as the object of research . Genotyping was performed using real-time PCR followed by restriction analysis. Statistical data processing was performed using the χ2 criterion to assess the correspondence between genotype distribution and the Hardy–Weinberg equilibrium. Results. Analysis of the allelic distribution of the PPARG gene revealed the prevalence of the C allele in the total sample (82% in the main group and 89% in the control group). The most common genotype was C/C (70% and 80%, respectively), which indicates its association with a lower predisposition to infectious complications. The distribution of genotypes was in accordance with the Hardy-Weinberg equilibrium (p > 0.05), confirming the representativeness of the sample. Conclusion. The PPARG C1431T polymorphism is a significant predictor of the risk of developing and relapsing purulent complications in patients with lower limb injuries. Carriers of the T allele exhibit an increased likelihood of a prolonged inflammatory response, which requires a personalized approach to antibiotic therapy and early immunocorrection. To improve the accuracy of the forecast, it is necessary to take into account covariates, namely: metabolic disorders (BMI ≥ 30 kg/m 2 , type 2 diabetes mellitus), cardiovascular pathologies (hypertension, coronary heart disease).