68Ga-PSMA PET/CT Identifies “Pseudo-progression” of Bone Lesions in Prostate Cancer Observed on 68Ga-DOTA-IBA PET/CT
We report a case where 68 Ga-PSMA PET/CT distinguished "pseudo-progression" from progression observed on 68 Ga-DOTA-IBA PET/CT. In a 75-year-old man with metastatic castration-resistant prostate cancer (mCRPC), 68 Ga-DOTA-IBA PET/CT revealed markedly increased tracer uptake in bone metastases compared with pretreatment imaging, suggesting radiologic progression. However, 68 Ga-PSMA-11 PET/CT images demonstrated the complete metabolic response (PERCIST 1.0), revealing "pseudo-progression" of bone lesions in 68 Ga-DOTA-IBA, especially when combined with clinical symptoms, PSA, and ALP levels.
Authors
- Shangjing Pang
- Dong Huang (ORCID: https://orcid.org/0000-0002-7483-4329)
- Na Zhang (ORCID: https://orcid.org/0000-0002-2414-9833)
- Yue Chen (ORCID: https://orcid.org/0000-0003-4088-7649)
- Jie Gong (ORCID: https://orcid.org/0000-0001-5897-7023)
Institutions
- Target (United States) (US)
- Southwest Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- Sichuan Mianyang 404 Hospital (CN)
Publication Details
- Journal
- Clinical Nuclear Medicine
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1097/rlu.0000000000006085
- Citations
- 1
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 1.52