Effect of Lidocaine on Quinine-Induced Tinnitus in Guinea Pigs: A Focus on the Auditory Cortex
The reversal of quinine-induced changes in Q10dB value and spontaneous firing activity by lidocaine suggests that these neural alterations are related to tinnitus. Similar results with salicylate further support the association between cortical changes and tinnitus, pointing to a possible shared central mechanism.
Authors
- Hirotsugu Kinoshita
- Mutsumi Kenmochi
- Shigeru Kasugai
- Manabu Komori (ORCID: https://orcid.org/0000-0001-8223-9186)
- Manabu Nakamura
- Kentaro Ochi (ORCID: https://orcid.org/0000-0003-4817-4117)
Institutions
- St. Marianna University School of Medicine (JP)
- Orchid Pharma (India) (IN)
Publication Details
- Journal
- Otology & Neurotology
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1097/mao.0000000000004616
- Primary Topic
- Hearing, Cochlea, Tinnitus, Genetics
- Type
- article
- Field-Weighted Citation Impact
- 0.00