Elevated lactate production exacerbates PM2.5-induced pulmonary fibrosis by stabilizing TGF-β1
Elevated lactate production in macrophages induced by PM2.5 inhibits the ubiquitination and degradation of TGF-β1 through the suppression of CHIP expression, thereby enhancing TGF-β1 secretion and exacerbating pulmonary fibrosis.
Authors
- Zhenjie Yu (ORCID: https://orcid.org/0000-0002-6850-3363)
- Jiayu Ren (ORCID: https://orcid.org/0000-0002-9863-8939)
- Shuping Zhang (ORCID: https://orcid.org/0000-0003-1586-0559)
- Zhihao Liu (ORCID: https://orcid.org/0000-0003-1644-0679)
- Ping Ye (ORCID: https://orcid.org/0000-0002-5591-6812)
- Wei Liu (ORCID: https://orcid.org/0000-0002-3915-5371)
- Huaiqing Wei (ORCID: https://orcid.org/0009-0005-5930-7917)
- Zheng Dong (ORCID: https://orcid.org/0000-0002-2067-4649)
- Sijin Liu
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1016/j.jare.2025.07.057
- Citations
- 4
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 6.07