Chronic Tenosynovitis Caused by <i>Mycobacterium terrae</i>: A Case Report Highlighting a Diagnostic Challenge

We report a rare case of chronic tenosynovitis of the upper extremity caused by Mycobacterium terrae, an infrequent and underdiagnosed pathogen. A 64-year-old man presented with persistent pain and swelling in the hand following a minor puncture wound. Despite multiple empirical treatments, including corticosteroids, antibiotics, and antifungals, the condition progressed over several months (Figure 1). Surgical intervention, histopathologic examination revealing granulomatous inflammation, and prolonged microbiological culture ultimately identified M terrae. Susceptibility-guided antimicrobial therapy resulted in complete clinical resolution. This case highlights the diagnostic complexity of M terrae infections and emphasizes the importance of considering atypical pathogens in cases of chronic tenosynovitis, especially when conventional therapies fail.

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Publication Details

Journal
Annals of Internal Medicine Clinical Cases
Published
2025-08-01
DOI
https://doi.org/10.7326/aimcc.2024.1321
Primary Topic
Mycobacterium research and diagnosis
Type
article
Field-Weighted Citation Impact
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article

Chronic Tenosynovitis Caused by Mycobacterium terrae: A Case Report Highlighting a Diagnostic Challenge

Pietro Antonini, A Giannini
Annals of Internal Medicine Clinical Cases
Mycobacterium research and diagnosis
article

Chronic Tenosynovitis Caused by Mycobacterium terrae: A Case Report Highlighting a Diagnostic Challenge

Pietro Antonini, A Giannini
article en

Abstract

We report a rare case of chronic tenosynovitis of the upper extremity caused by Mycobacterium terrae, an infrequent and underdiagnosed pathogen. A 64-year-old man presented with persistent pain and swelling in the hand following a minor puncture wound. Despite multiple empirical treatments, including corticosteroids, antibiotics, and antifungals, the condition progressed over several months (Figure 1). Surgical intervention, histopathologic examination revealing granulomatous inflammation, and prolonged microbiological culture ultimately identified M terrae. Susceptibility-guided antimicrobial therapy resulted in complete clinical resolution. This case highlights the diagnostic complexity of M terrae infections and emphasizes the importance of considering atypical pathogens in cases of chronic tenosynovitis, especially when conventional therapies fail.

Annals of Internal Medicine Clinical CasesVol. 4(8)
Clinica Luganese Moncucco (CH)
Zero hunger
Openalex Percentile: Top 72%
Mycobacterium research and diagnosis
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