An Unusual Case of Abdominal Pain in the Postpartum Period: A Case Report of Vernix Caseosa Peritonitis

Vernix caseosa peritonitis is a rare cause of peritonitis that can occur in the postpartum period. We present a case of diffuse abdominal pain 5-week postpartum that was unrelieved with antibiotics. Computed tomography of the abdomen showed phlegmonous peritonitis with nodularities. Omental node biopsy revealed necroinflammatory debris and multinucleate giant cells suggesting a noninfectious granulomatous process. Treatment with steroids resulted in significant improvement and decreased nodularity. Vernix caseosa peritonitis is caused by an inflammatory response attributable to maternal amniotic fluid spilling into the peritoneal cavity. It should be considered in the differential diagnosis of postcesarean acute abdomen thereby avoiding laparotomy and the unnecessary work-up and treatment.

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Publication Details

Journal
Annals of Internal Medicine Clinical Cases
Published
2025-08-01
DOI
https://doi.org/10.7326/aimcc.2025.0024
Primary Topic
Immunodeficiency and Autoimmune Disorders
Type
article
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article

An Unusual Case of Abdominal Pain in the Postpartum Period: A Case Report of Vernix Caseosa Peritonitis

Jin Hwa Lee, Justin Cruz, R Amin
Annals of Internal Medicine Clinical Cases
Immunodeficiency and Autoimmune Disorders
article

An Unusual Case of Abdominal Pain in the Postpartum Period: A Case Report of Vernix Caseosa Peritonitis

Jin Hwa Lee, Justin Cruz, R Amin
article en

Abstract

Vernix caseosa peritonitis is a rare cause of peritonitis that can occur in the postpartum period. We present a case of diffuse abdominal pain 5-week postpartum that was unrelieved with antibiotics. Computed tomography of the abdomen showed phlegmonous peritonitis with nodularities. Omental node biopsy revealed necroinflammatory debris and multinucleate giant cells suggesting a noninfectious granulomatous process. Treatment with steroids resulted in significant improvement and decreased nodularity. Vernix caseosa peritonitis is caused by an inflammatory response attributable to maternal amniotic fluid spilling into the peritoneal cavity. It should be considered in the differential diagnosis of postcesarean acute abdomen thereby avoiding laparotomy and the unnecessary work-up and treatment.

Annals of Internal Medicine Clinical CasesVol. 4(8)
Northside Hospital (US), Gwinnett College (US), Georgia Gwinnett College (US)
Openalex Percentile: Top 78%
Immunodeficiency and Autoimmune Disorders
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An Unusual Case of Abdominal Pain in the Postpartum Period: A Case Report of Vernix Caseosa Peritonitis — Jin Hwa Lee, Justin Cruz, et al. · Annals of Internal Medicine Clinical Cases (2025) | TGRS Research Map | TGRS