Characterization of the clinical and laboratory phenotype of hemophilia carriers and trends of utilization of hemostatic therapies: analysis of the American Thrombosis and Hemostasis Network dataset
Our study confirms prior reports of increased bleeding in reproductive-age HCs and identifies lifelong joint bleeding risk. While the rising trend in hemostatic therapy use suggests growing awareness of bleeding tendencies, age-dependent increase in FVIII levels in hemophilia A carriers emphasizes the need for developing tailored management strategies across the lifespan for this population.
Authors
- Steven W. Pipe (ORCID: https://orcid.org/0000-0003-2558-2089)
- Roshni Kulkarni (ORCID: https://orcid.org/0000-0001-9372-3184)
- Anjali Sharathkumar (ORCID: https://orcid.org/0000-0003-4574-6175)
- Peter A. Kouides (ORCID: https://orcid.org/0000-0002-3857-8313)
- Jianzhong Hu (ORCID: https://orcid.org/0000-0002-0736-1488)
- Alison Currie
- N. Swaminathan
Institutions
- University of Iowa (US)
- University of Michigan (US)
- University of Iowa Hospitals and Clinics (US)
- Mary M. Gooley Hemophilia Center (US)
- American Thrombosis and Hemostasis Network (US)
- Michigan State University (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Research and Practice in Thrombosis and Haemostasis
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1016/j.rpth.2025.102994
- Citations
- 1
- Primary Topic
- Hemophilia Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 1.77