Autoantibody profiling to predict response to the anti-PD-1 therapy, pembrolizumab, in rare tumors
The predictive potential of AAbs as biomarkers of ICI therapy is promising. Further evaluation in larger cohorts is needed to validate our findings and elucidate the underlying mechanism.
Authors
- Lucía Castillo (ORCID: https://orcid.org/0000-0002-6524-4984)
- Aung Naing (ORCID: https://orcid.org/0000-0002-4803-8513)
- Mohamed H. Derbala (ORCID: https://orcid.org/0000-0002-0420-3521)
- Evan Kwiatkowski (ORCID: https://orcid.org/0000-0001-8398-8429)
- Serdar A. Gurses (ORCID: https://orcid.org/0000-0002-8781-4554)
- Petra Budde (ORCID: https://orcid.org/0000-0001-8991-3495)
- Siqing Fu (ORCID: https://orcid.org/0000-0002-1933-0419)
- Behnaz Ahangarian Abhari
- F. Meric-Bernstam
- D.S. Hong
- Justin T. Moyers (ORCID: https://orcid.org/0000-0001-5139-1652)
- Joud Hajjar (ORCID: https://orcid.org/0000-0003-4633-1043)
- Abdulrazzak Zarifa (ORCID: https://orcid.org/0000-0002-4649-2456)
- Mohamed A. Gouda (ORCID: https://orcid.org/0000-0003-4829-6739)
- Bettzy Stephen (ORCID: https://orcid.org/0000-0003-1653-2012)
- H-D Zucht
- Jeffrey How (ORCID: https://orcid.org/0000-0003-1446-9574)
- E. Rodriguez
- Matthias Bräutigam
- Ann-Sophie Lindemann
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Angeles Clinic and Research Institute (US)
- Texas Children's Hospital (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1016/j.esmoop.2025.105518
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Sanofi
- American Society of Clinical Oncology
- Karyopharm Therapeutics
- Regeneron Pharmaceuticals
- Cholangiocarcinoma Foundation
- Society for Immunotherapy of Cancer
- Millendo Therapeutics
- Mersana Therapeutics
- Incyte
- Calithera Biosciences
- NGM Biopharmaceuticals
- Seagen
- European Organisation for Research and Treatment of Cancer
- European Society for Medical Oncology
- STCube
- Servier
- EMD Serono
- University of Texas MD Anderson Cancer Center
- National Cancer Institute
- Janssen Biotech