Autoantibody profiling to predict response to the anti-PD-1 therapy, pembrolizumab, in rare tumors

The predictive potential of AAbs as biomarkers of ICI therapy is promising. Further evaluation in larger cohorts is needed to validate our findings and elucidate the underlying mechanism.

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Publication Details

Journal
ESMO Open
Published
2025-08-01
DOI
https://doi.org/10.1016/j.esmoop.2025.105518
Citations
1
Primary Topic
Cancer Immunotherapy and Biomarkers
Type
article
Field-Weighted Citation Impact
1.05

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article

Autoantibody profiling to predict response to the anti-PD-1 therapy, pembrolizumab, in rare tumors

Lucía Castillo, Aung Naing, Mohamed H. Derbala, Evan Kwiatkowski et al.
1 citations
ESMO Open
Cancer Immunotherapy and Biomarkers
1.05
article

Autoantibody profiling to predict response to the anti-PD-1 therapy, pembrolizumab, in rare tumors

Lucía Castillo, Aung Naing, Mohamed H. Derbala, Evan Kwiatkowski, Serdar A. Gurses, Petra Budde, Siqing Fu, Behnaz Ahangarian Abhari, F. Meric-Bernstam, D.S. Hong, Justin T. Moyers, Joud Hajjar, Abdulrazzak Zarifa, Mohamed A. Gouda, Bettzy Stephen, H-D Zucht, Jeffrey How, E. Rodriguez, Matthias Bräutigam, Ann-Sophie Lindemann
article en
1 citations

Abstract

The predictive potential of AAbs as biomarkers of ICI therapy is promising. Further evaluation in larger cohorts is needed to validate our findings and elucidate the underlying mechanism.

ESMO OpenVol. 10(8)
The University of Texas MD Anderson Cancer Center (US), Angeles Clinic and Research Institute (US), Texas Children's Hospital (US), The University of Texas Health Science Center at Houston (US)
Bristol-Myers Squibb, Eli Lilly and Company, Pfizer, Sanofi, American Society of Clinical Oncology, Karyopharm Therapeutics, Regeneron Pharmaceuticals, Cholangiocarcinoma Foundation, Society for Immunotherapy of Cancer, Millendo Therapeutics, Mersana Therapeutics, Incyte, Calithera Biosciences, NGM Biopharmaceuticals, Seagen, European Organisation for Research and Treatment of Cancer, European Society for Medical Oncology, STCube, Servier, EMD Serono, University of Texas MD Anderson Cancer Center, National Cancer Institute, Janssen Biotech
Good health and well-being
Openalex Percentile: Top 19%
Cancer Immunotherapy and Biomarkers
1.05
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