Modern concepts of basic therapy for diffuse dyshormonal dysplasia of the mammary glands

The presented work is devoted to modern concepts of basic therapy of dyshormonal dysplasia – the most common diffuse disease of the mammary glands. In Russia, one of the most popular medications for the specific correction of mastalgia–mastodynia associated with this disease is Mastodinon. The active component of the drug – the extract of Vitex agnus-castus (chaste tree, monk’s pepper) contains the flavonoid casticin, which determines the therapeutic potential of this plant. The authors present the latest data from the world literature on the clinical and biological effects of сasticin as well as its molecular effects on the processes of epigenetic rearrangements in benign breast dysplasia. Also the potential role of casticin in the prevention of cancer was assessed.