Towards Personalized Psychiatry: Foreign Experience in Psychopharmacogenetics

The work presents research into foreign experience of the shif t to personalized psychiatry when taking a psychopharmacogenetic approach. Contemporary trends in the development of genetically oriented treatment of psychiatric disorders are identified in recent international studies. A systematic review of the relevant literature reveals a growing interest in the individualized prescription of drugs based on a patient’s genetic profile as a means of increasing therapeutic ef fectiveness and reducing the risk of side ef fects. In order to evaluate the introduction of psychopharmacogenetics in foreign countries, the review includes data on diagnostic methods, drug prescription protocols, and clinical outcomes. The individual selection of dosages of antidepressants and antipsychotics is shown to have led to a significant increase in the ef fectiveness of treatments for a number of psychiatric diseases. Psychopharmacogenetics thus represents a promising area of modern psychiatry, having the potential to significantly improve the quality of life of patients. However, further clinical trials are needed before introducing appropriate technologies into healthcare practice. Limitations of the study include the small sizes of the study populations and the lack of representativeness of the samples. For this reason, caution should be taken when extrapolating the findings to the general population.