Hypermobile Ehlers-Danlos Syndrome: Cerebrovascular, Autonomic and Neuropathic Features
This study provided evidence of cerebrovascular dysregulation with reduced orthostatic cerebral blood flow velocity associated with symptoms of cerebral hypoperfusion, frequent small fiber neuropathy, and widespread but mild autonomic failure in hEDS.
Authors
- William J. Mullally (ORCID: https://orcid.org/0000-0001-7288-5643)
- Donna Felsenstein
- Sadie P. Marciano
- Matthew P. Giannetti (ORCID: https://orcid.org/0000-0003-3655-1835)
- Péter Novák (ORCID: https://orcid.org/0000-0002-5971-1208)
- A. Veronica Witte (ORCID: https://orcid.org/0000-0001-9054-6688)
- Jeff M. Milunsky
- Jennifer Nicoloro‐SantaBarbara (ORCID: https://orcid.org/0000-0002-6423-3554)
- Mark C. Fishman (ORCID: https://orcid.org/0000-0003-0033-541X)
- Mariana Castells (ORCID: https://orcid.org/0000-0001-6451-0163)
- Joel B. Krier (ORCID: https://orcid.org/0000-0001-7981-3618)
- David Pilgrim (ORCID: https://orcid.org/0000-0001-8140-8734)
- Arabella Warren
- David M. Systrom (ORCID: https://orcid.org/0000-0002-9610-6330)
- Khosro Farhad
- Matthew J. Hamilton (ORCID: https://orcid.org/0000-0002-1149-1883)
- Aubrey Milunsky
Institutions
- Harvard University Press (US)
- Center for Human Genetics (US)
- Pediatrics and Genetics (US)
- Mast Cell Disease Society (US)
- Harvard Stem Cell Institute (US)
- Pulmonary and Critical Care Associates (US)
- Mass General Brigham (US)
Publication Details
- Journal
- American Journal of Medicine Open
- Published
- 2025-07-18
- DOI
- https://doi.org/10.1016/j.ajmo.2025.100111
- Citations
- 3
- Primary Topic
- Connective tissue disorders research
- Type
- article
- Field-Weighted Citation Impact
- 5.45