Mechanisms of histopathologic vascular damage caused by pancreatic juice leakage: Implications for preventing hemorrhagic complications
The activation of pancreatic proteases through mixing with intestinal fluids is a major factor causing histologic damage to the arterial media, leading to aneurysm formation and rupture of the vascular wall. Developing methods for the localized and continuous administration of protease inhibitors around vascular stumps could reduce life-threatening bleeding complications after pancreatic surgery.
Authors
- Tetsuo Ushiku (ORCID: https://orcid.org/0000-0002-1763-8380)
- Kento Mitsuhashi
- Hiroyuki Abé (ORCID: https://orcid.org/0000-0003-2618-7494)
- Yasuteru Urano (ORCID: https://orcid.org/0000-0002-1220-6327)
- Kazuhiro Mori (ORCID: https://orcid.org/0000-0003-1085-4096)
- Toru Komatsu (ORCID: https://orcid.org/0000-0002-9268-6964)
- Natsuko F. Inagaki (ORCID: https://orcid.org/0000-0002-6309-9023)
- Kiyoshi Hasegawa (ORCID: https://orcid.org/0000-0001-8734-740X)
- Takeaki Ishizawa (ORCID: https://orcid.org/0000-0002-9534-6973)
- Yusuke Seki
- Genki Watanabe (ORCID: https://orcid.org/0000-0002-4433-5035)
- Taichi Ito
Institutions
- Asahi General Hospital (JP)
- Osaka Metropolitan University (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Surgery
- Published
- 2025-08-05
- DOI
- https://doi.org/10.1016/j.surg.2025.109591
- Citations
- 1
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Japan Agency for Medical Research and Development
- University of Tokyo