Effect of calcium hydroxide and adipose-derived stem cell conditioned medium (ADSCs-CM) combination on reparative dentin formation in Wistar rats through RUNX-2 and OPN expression
The addition of ADSCs-CM to Ca(OH)<sub>2</sub> enhances reparative dentinogenesis by upregulating RUNX-2 and OPN expression. This combination therapy may serve as a biologically favorable alternative for direct pulp capping procedures.
Authors
- Dian Agustin Wahjuningrum (ORCID: https://orcid.org/0000-0002-5168-1016)
- Radixtio Auzan Fepiosandi
- Galih Sampoerno
Institutions
- Universitas Airlangga (ID)
- Ragas Dental College & Hospital (IN)
Publication Details
- Journal
- Journal of Oral Biology and Craniofacial Research
- Published
- 2025-08-05
- DOI
- https://doi.org/10.1016/j.jobcr.2025.07.001
- Primary Topic
- Bone and Dental Protein Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universitas Airlangga