Metabolites derived from bacterial isolates of the human skin microbiome inhibit <i>Staphylococcus aureus</i> biofilm formation

The skin is constantly exposed to the environment and consequently to numerous pathogens. The bacterial community that colonizes healthy skin is thought to play an important role in protecting us against infections. <i>S. aureus</i> is a leading cause of death worldwide and is frequently involved in several types of infections, including skin and soft tissue infections. Its ability to adhere to surfaces and produce biofilms is considered an important virulence factor. Here, we analyzed the activity of different species of bacteria isolated from healthy skin on <i>S. aureus</i> biofilm formation. We found that some species of <i>Staphylococcus</i> and <i>Bacillus</i> can reduce <i>S. aureus</i> biofilm formation, although a generally lower level of inhibitory activity was observed compared to <i>S. epidermidis</i> isolates. Among <i>S. epidermidis</i> isolates, strength of activity was dependent on the strain. Our data highlight the importance of mining the skin microbiome for isolates that could help combat skin pathogens.