Severe Catatonia in Early-Onset Schizophrenia Successfully Treated With Lorazepam and Aripiprazole in a 16-Year-Old Girl: A Case Report

Catatonia is a severe but often underrecognized neuropsychiatric condition in adolescents. We present the case of a 16-year-old girl with early-onset schizophrenia who developed acute catatonic symptoms during a relapse following risperidone reintroduction. The clinical presentation raised a diagnostic dilemma with neuroleptic malignant syndrome (NMS). A lorazepam trial led to partial improvement, but symptom resolution occurred only after adding low-dose aripiprazole. This case underscores the importance of early identification of catatonia in adolescents, careful differentiation from NMS, and the potential benefit of combined lorazepam and aripiprazole treatment in catatonic schizophrenia.

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Publication Details

Journal
Cureus
Published
2025-08-05
DOI
https://doi.org/10.7759/cureus.89413
Primary Topic
Electroconvulsive Therapy Studies
Type
article
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article

Severe Catatonia in Early-Onset Schizophrenia Successfully Treated With Lorazepam and Aripiprazole in a 16-Year-Old Girl: A Case Report

Linda Rachidi, Ghizlane Khaloui, Ghizlane Benjelloun, Amal Mabkhout et al.
Cureus
Electroconvulsive Therapy Studies
article

Severe Catatonia in Early-Onset Schizophrenia Successfully Treated With Lorazepam and Aripiprazole in a 16-Year-Old Girl: A Case Report

Linda Rachidi, Ghizlane Khaloui, Ghizlane Benjelloun, Amal Mabkhout, Salma Abchir
article en

Abstract

Catatonia is a severe but often underrecognized neuropsychiatric condition in adolescents. We present the case of a 16-year-old girl with early-onset schizophrenia who developed acute catatonic symptoms during a relapse following risperidone reintroduction. The clinical presentation raised a diagnostic dilemma with neuroleptic malignant syndrome (NMS). A lorazepam trial led to partial improvement, but symptom resolution occurred only after adding low-dose aripiprazole. This case underscores the importance of early identification of catatonia in adolescents, careful differentiation from NMS, and the potential benefit of combined lorazepam and aripiprazole treatment in catatonic schizophrenia.

CureusVol. 17(8)
Mother Hospital (IN), University of Hassan II Casablanca (MA)
Openalex Percentile: Top 77%
Electroconvulsive Therapy Studies
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