Development of rematuration of canine chemically induced hepatic progenitor cells using 3D rocking culture
3D rocking culture markedly enhanced liver-specific gene and protein expression, producing functional liver spheroids. These findings underscore the potential of 3D rocking cultures to create reliable, <i>in vivo</i>-like liver models for research and therapeutic applications.
Authors
- Kaoruko Kikuchi
- Masaharu Hisasue (ORCID: https://orcid.org/0000-0003-3738-6659)
- Akihide Kamiya (ORCID: https://orcid.org/0000-0002-2552-4236)
- Yoko Yamada (ORCID: https://orcid.org/0000-0001-8273-0012)
- Hirotaka Igarashi (ORCID: https://orcid.org/0000-0002-0870-8586)
- Suguru Nitta (ORCID: https://orcid.org/0000-0001-6642-607X)
- Sakurako Neo
Institutions
- Tokai University (JP)
- Azabu University (JP)
Publication Details
- Journal
- Regenerative Therapy
- Published
- 2025-08-05
- DOI
- https://doi.org/10.1016/j.reth.2025.06.002
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00