Asymmetric Isochalcogenourea-Catalyzed Synthesis of 3,4-Dihydropyrans via (4+2)-Cycloadditions of Ethyl But-3-ynoate with Michael Acceptors
We herein report the use of ethyl but-3-ynoate as a C2 building block for asymmetric (4+2)-heterocycloadditions with various Michael acceptors. Upon using chiral isochalcogenoureas as Lewis base catalysts, these reactions can be carried out with good to excellent control of the regioselectivity, diastereoselectivity, and enantioselectivity.
Authors
- Magdalena Piringer
- Anna Scheucher
- Mario Hofer
- Mario Waser (ORCID: https://orcid.org/0000-0002-8421-8642)
- Lukas S. Vogl
Institutions
- Johannes Kepler University of Linz (AT)
- Kepler Universitätsklinikum (AT)
Publication Details
- Journal
- Synlett
- Published
- 2025-07-18
- DOI
- https://doi.org/10.1055/a-2659-8340
- Citations
- 2
- Primary Topic
- Asymmetric Synthesis and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 1.87