Chemotherapy Selection Can Differentially Impact Normal Cells

Major Finding: Different chemotherapies elicit cell type–specific effects on mutation load in normal blood cells.Concept: Chemotherapies can cause single-base substitutions that prematurely age hematopoietic stem and progenitor cells.Impact: These findings may inform the selection of specific chemotherapeutics that minimize damage to normal tissue.

Publication Details

Journal
Cancer Discovery
Published
2025-01-01
DOI
https://doi.org/10.1158/2159-8290.cd-rw2025-067
Primary Topic
Mathematical Biology Tumor Growth
Type
article
Field-Weighted Citation Impact
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article

Chemotherapy Selection Can Differentially Impact Normal Cells

Cancer Discovery
Mathematical Biology Tumor Growth
article

Chemotherapy Selection Can Differentially Impact Normal Cells

article en

Abstract

Major Finding: Different chemotherapies elicit cell type–specific effects on mutation load in normal blood cells.Concept: Chemotherapies can cause single-base substitutions that prematurely age hematopoietic stem and progenitor cells.Impact: These findings may inform the selection of specific chemotherapeutics that minimize damage to normal tissue.

Cancer Discovery
Zero hunger
Openalex Percentile: Top 77%
Mathematical Biology Tumor Growth
DOISourceOpenAlex
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Chemotherapy Selection Can Differentially Impact Normal Cells · Cancer Discovery (2025) | TGRS Research Map | TGRS