Exercise Remodels the Microbiome to Boost Antitumor Immunity

Major Finding: Exercise enhances gut microbial production of formate, a metabolite that drives CD8+ T cell-mediated tumor suppression. Concept: Microbiota-derived formate activates NRF2 in CD8+ T cells to drive antitumor effector function.Impact: Exercise-induced microbiome metabolites shape antitumor immunity, revealing new targets to enhance immunotherapy efficacy.

Publication Details

Journal
Cancer Discovery
Published
2025-01-01
DOI
https://doi.org/10.1158/2159-8290.cd-rw2025-068
Primary Topic
Gut microbiota and health
Type
article
Field-Weighted Citation Impact
0.00
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article

Exercise Remodels the Microbiome to Boost Antitumor Immunity

Cancer Discovery
Gut microbiota and health
article

Exercise Remodels the Microbiome to Boost Antitumor Immunity

article en

Abstract

Major Finding: Exercise enhances gut microbial production of formate, a metabolite that drives CD8+ T cell-mediated tumor suppression. Concept: Microbiota-derived formate activates NRF2 in CD8+ T cells to drive antitumor effector function.Impact: Exercise-induced microbiome metabolites shape antitumor immunity, revealing new targets to enhance immunotherapy efficacy.

Cancer Discovery
Zero hunger
Openalex Percentile: Top 82%
Gut microbiota and health
DOISourceOpenAlex
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Exercise Remodels the Microbiome to Boost Antitumor Immunity · Cancer Discovery (2025) | TGRS Research Map | TGRS