A brief overview of Chandipura virus

Chandipura Virus (CHPV), part of the Rhabdoviridae family, causes outbreaks primarily in rural India, affecting children with influenza-like symptoms and neurological issues. Transmitted by vectors like mosquitoes, ticks, and sand flies, CHPV has a negative-sense RNA genome encoding five proteins (N, P, M, G, L). The P protein is crucial for the viral life cycle, while the M protein is highly lethal. Currently, no specific treatment exists, but symptomatic management includes using mannitol to reduce brain edema. A Vero cell- based vaccine candidate has shown promise as a preventive measure. Effective control involves vector management, maintaining nutrition, hygiene, and increasing awareness in rural areas. Until an effective antiviral agent is developed, preventive measures such as public health education and vector containment remain critical in curbing CHPV outbreaks.