Effectiveness of Topical Hemocoagulase on the Healing of Surgical Wounds in the Neck: A Randomized Clinical Trial

Abstract Background This study aims to evaluate the role and effectiveness of topical hemocoagulase in the healing process of surgical neck wounds in oral cancer patients undergoing surgery as the primary treatment modality. Methodology This prospective, parallel, double-blinded randomized clinical trial was conducted on oral cancer patients planned for surgical resection and neck dissection. The study included 22 patients divided into two groups: Group I received topical hemocoagulase, and Group II served as the control. Quantitative assessment was performed using the DermaLab Combo device to measure dermal thickness, collagen level, elasticity, viscoelasticity, and retraction time. Qualitative assessment was performed using the Patient and Observer Scar Assessment Scale (POSAS). Results Analysis of quantitative variables revealed a significant improvement in dermal thickness, collagen levels, elasticity, viscoelasticity, and retraction time in Group I compared to Group II at both the 1st and 4th postoperative weeks. Qualitative assessment using POSAS showed a notable reduction in pain and improved overall scar appearance in the hemocoagulase group. These findings are consistent with previous studies that have shown the effectiveness of hemocoagulase in enhancing wound healing and reducing scar formation. Conclusion Topical hemocoagulase significantly enhances wound healing in surgical neck wounds of oral cancer patients, providing both quantitative improvements and higher patient satisfaction.