Wilms Tumor, Version 2.2025, NCCN Clinical Practice Guidelines In Oncology

The NCCN Clinical Practice Guidelines (NCCN Guidelines) for Wilms Tumor (WT; nephroblastoma) cover strategies for the screening, diagnosis, and treatment of WT, which is the most frequent primary kidney tumor in children. WT can generally be separated into 2 histology types: favorable histology WT and anaplastic WT. Five-year survival is high for children with favorable histology WT who receive appropriate treatment; however, survival rates are much lower for patients who present with higher stage diffuse anaplastic WT. Treatment of WT can range from surgery alone to surgery plus intensive chemotherapy and radiation depending on whether the tumor is unilateral or bilateral, histology, and local stage. The goal of therapy is to maximize cure while minimizing long-term toxicities. The content featured in this issue covers the NCCN panel's recommendations for overall management of both favorable histology WT and anaplastic WT.

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Institutions

Publication Details

Journal
Journal of the National Comprehensive Cancer Network
Published
2025-08-01
DOI
https://doi.org/10.6004/jnccn.2025.0037
Citations
2
Primary Topic
Renal and related cancers
Type
article
Field-Weighted Citation Impact
1.61
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article

Wilms Tumor, Version 2.2025, NCCN Clinical Practice Guidelines In Oncology

Susan M. Hiniker, Amy L. Walz, Kathleen Kieran, Daniel S. Rhee et al.
2 citations
Journal of the National Comprehensive Cancer Network
Renal and related cancers
1.61
article

Wilms Tumor, Version 2.2025, NCCN Clinical Practice Guidelines In Oncology

Susan M. Hiniker, Amy L. Walz, Kathleen Kieran, Daniel S. Rhee, Mark Ranalli, Daniel M. Green, Jasreman Dhillon, Erin G. Brown, Frank M. Balis, Iain MacEwan, Julián A. Martínez-Agosto, Daniel M. Geynisman, Ami Vijay Desai, Kelly K. Horst, Janet Yoon, Bailee Sliker, Elizabeth Anne Mullen, Denise A. Rokitka, Jamie M. Aye, Jonathan E. Wickiser, Daniel J. Benedetti, Sarah Montgomery, Shelly Cook, Rama Jasty‐Rao, Brandon Brown, Douglas Fair, Erin S. Murphy, Matthew A. Zapala, Navin Pinto, Marissa Just, Amy J. Armstrong, Chi Lin
article en
2 citations

Abstract

The NCCN Clinical Practice Guidelines (NCCN Guidelines) for Wilms Tumor (WT; nephroblastoma) cover strategies for the screening, diagnosis, and treatment of WT, which is the most frequent primary kidney tumor in children. WT can generally be separated into 2 histology types: favorable histology WT and anaplastic WT. Five-year survival is high for children with favorable histology WT who receive appropriate treatment; however, survival rates are much lower for patients who present with higher stage diffuse anaplastic WT. Treatment of WT can range from surgery alone to surgery plus intensive chemotherapy and radiation depending on whether the tumor is unilateral or bilateral, histology, and local stage. The goal of therapy is to maximize cure while minimizing long-term toxicities. The content featured in this issue covers the NCCN panel's recommendations for overall management of both favorable histology WT and anaplastic WT.

Journal of the National Comprehensive Cancer NetworkVol. 23(8)
Fox Chase Cancer Center (US), Roswell Park Comprehensive Cancer Center (US), Barnes-Jewish Hospital (US), City Of Hope National Medical Center (US), St. Jude Children's Research Hospital (US), Cleveland Clinic (US), Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA), The University of Texas MD Anderson Cancer Center (US), Breast Cancer Research Foundation (US), University of Utah (US), The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US), UC San Diego Health System (US), Huntsman Cancer Institute (US), Cancer Institute (WIA) (IN), Susan Thompson Buffett Foundation (US), WinnMed (US), Moffitt Cancer Center (US), Fred Hutch Cancer Center (US), Children's Hospital Colorado (US), Southwestern Medical Center (US), Jewish Hospital (US), University of Wisconsin Carbone Cancer Center (US), Sidney Kimmel Cancer Center (US), University Hospitals Seidman Cancer Center (US), University of Colorado Cancer Center (US), Dana-Farber Brigham Cancer Center (US), UCSF Helen Diller Family Comprehensive Cancer Center (US), Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Moores Cancer Center, University of Chicago Medicine Comprehensive Cancer Center, UCLA Jonsson Comprehensive Cancer Center, Vanderbilt-Ingram Cancer Center, Stanford Cancer Institute, Fred and Pamela Buffett Cancer Center, UC Davis Comprehensive Cancer Center, Harold C. Simmons Comprehensive Cancer Center, O'Neal Comprehensive Cancer Center, National Comprehensive Cancer Network, Indiana University (US), University of Pennsylvania (US), University of California, Davis (US), The University of Texas Southwestern Medical Center (US), University of Colorado Denver (US)
Good health and well-being
Openalex Percentile: Top 16%
Renal and related cancers
1.61
DOISourceOpenAlex
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