Is There Any Possible Relationship Between Antenatal Hydronephrosis and Prenatal Androgen Exposure? An Analysis Using the 2D:4D Digit Ratio

The observation of significantly higher 2D:4D ratios in newborns with antenatal hydronephrosis may suggest a possible association with decreased prenatal androgen exposure. While the 2D:4D ratio is generally expected to be higher in females and lower in males, the finding of higher ratios in newborns with hydronephrosis may indicate a reduced androgen effect during fetal development in these cases. Although this finding is consistent with the fact that hydronephrosis is more frequently observed in male fetuses, it should be interpreted with caution and supported by further studies.