<scp>USP15</scp> Drives <scp>NSCLC</scp> Progression and Chemoresistance, Potentially via Regulation of the <scp>U2</scp> ‐Type Spliceosomal Complex
This study demonstrates the oncogenic role of USP15 in NSCLC, highlighting its contribution to tumor progression, chemoresistance, and RNA processing. The findings provide mechanistic insights into how USP15 may drive NSCLC pathogenesis through modulation of spliceosome-associated proteins. These results support the potential of USP15 as both a diagnostic biomarker and a therapeutic target in NSCLC.
Authors
- Chien‐Chih Chiu (ORCID: https://orcid.org/0000-0001-7307-2468)
- Wangta Liu (ORCID: https://orcid.org/0000-0002-4022-4848)
- I‐Ling Lin (ORCID: https://orcid.org/0000-0001-7022-4315)
- Wenhua Qiu
- Sheng‐Kai Hsu
- Ching‐Hung Hsieh
- Chon‐Kit Chou (ORCID: https://orcid.org/0000-0002-9087-3109)
Institutions
- National Sun Yat-sen University (TW)
- Kaohsiung Medical University (TW)
- University of Macau (MO)
- Kaohsiung Medical University Chung-Ho Memorial Hospital (TW)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/cam4.71055
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Sun Yat-sen University
- United Mitochondrial Disease Foundation
- National Kaohsiung University of Science and Technology
- Kaohsiung Medical University
- Universidade de Macau
- Fundo para o Desenvolvimento das Ciências e da Tecnologia
- National Science and Technology Council