Mitigating organophosphate nerve agent, soman (GD), induced long-term neurotoxicity: Saracatinib, a Src Tyrosine Kinase inhibitor, as a potential countermeasure
Long-term SAR treatment revealed disease-modifying effects by protecting the brain from soman induced neuroinflammation and neurodegeneration, while also reducing severity of spontaneous seizures. Furthermore, SAR mitigated some soman induced behavioral impairments and brain MRI. These findings highlight the therapeutic potential of Src tyrosine kinase inhibition in soman-induced chronic neurotoxicity.
Authors
- Thimmasettappa Thippeswamy (ORCID: https://orcid.org/0000-0002-9326-1896)
- Sridhar S. Kannurpatti
- Luis G. Giménez‐Lirola (ORCID: https://orcid.org/0000-0002-4407-7996)
- Suraj S. Vasanthi (ORCID: https://orcid.org/0009-0006-2762-1933)
- Nyzil Massey (ORCID: https://orcid.org/0000-0002-2816-1848)
- Hyunmook Im
- Claire Holtkamp
- Chong Wang (ORCID: https://orcid.org/0000-0003-4489-4344)
- Christina Meyer (ORCID: https://orcid.org/0000-0002-8714-1089)
- Nikhil S. Rao
- Avinash S Bevoor
Institutions
- Rutgers, The State University of New Jersey (US)
- University of Kentucky (US)
- Iowa State University (US)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-08-05
- DOI
- https://doi.org/10.1186/s12974-025-03520-5
- Citations
- 2
- Primary Topic
- Pesticide Exposure and Toxicity
- Type
- article
- Field-Weighted Citation Impact
- 3.50