Brand‐Specific Differences in the Cytotoxicity of Clear Aligner Materials
Clear aligner materials showed varying levels of cytotoxicity, with Invisalign and Spark exhibiting the most pronounced effects, while Essix PLUS demonstrated lower cytotoxicity under certain conditions. These findings highlight the importance of material formulation and manufacturing processes in ensuring safety. Further research is needed to optimise aligner materials for both clinical efficacy and biocompatibility.
Authors
- Inês Francisco (ORCID: https://orcid.org/0000-0002-3283-5104)
- Francisco Vale (ORCID: https://orcid.org/0000-0003-2615-2929)
- Ana Cristina Gonçalves (ORCID: https://orcid.org/0000-0003-1470-4802)
- Mafalda Laranjo (ORCID: https://orcid.org/0000-0003-0689-6007)
- Raquel Travassos (ORCID: https://orcid.org/0000-0001-8937-361X)
- Catarina de J Nunes (ORCID: https://orcid.org/0000-0001-9944-7280)
- Carlos Miguel Marto (ORCID: https://orcid.org/0000-0001-9269-5417)
- Maria Filomena Botelho (ORCID: https://orcid.org/0000-0001-7202-1650)
- Anabela Paula (ORCID: https://orcid.org/0000-0001-6154-4173)
- Maria Serra (ORCID: https://orcid.org/0009-0005-7736-2207)
- Catarina Mestre (ORCID: https://orcid.org/0000-0003-4884-1039)
- Inês P. Fernandes (ORCID: https://orcid.org/0000-0003-4303-1424)
Institutions
- University of Coimbra (PT)
Publication Details
- Journal
- Orthodontics and Craniofacial Research
- Published
- 2025-08-05
- DOI
- https://doi.org/10.1111/ocr.70009
- Primary Topic
- biodegradable polymer synthesis and properties
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Foundation for Science and Technology