Identification of clinically relevant profiles in colorectal cancer through integrated analysis of bacterial DNA and metabolome in serum
After integrating the data resulting from the bioinformatics and statistical analyses, we obtained different profiles in colorectal cancer population and controls, regardless of the subjects' age, gender and body mass index. Serum levels of Firmicutes and threonic acid were the most relevant characteristics that could help differentiate both groups, achieving an excellent predictive accuracy in this discovery cohort (area under the ROC curve = 0.95). Although these results should be validated in other cohorts through multicenter studies, we consider that our data could be relevant and applicable to the early diagnosis of colorectal cancer.
Authors
- Dulcenombre Gómez‐Garré (ORCID: https://orcid.org/0000-0002-5056-6489)
- Inmaculada Domínguez-Serrano (ORCID: https://orcid.org/0000-0002-7420-7480)
- Sofía de la Serna (ORCID: https://orcid.org/0000-0002-0046-6236)
- Pilar Iniesta (ORCID: https://orcid.org/0000-0002-1259-9810)
- Juan Vicente-Valor (ORCID: https://orcid.org/0000-0001-9319-5107)
- Antonio José Torres García (ORCID: https://orcid.org/0000-0002-9472-854X)
- Mateo Paz-Cabezas (ORCID: https://orcid.org/0000-0003-4144-8381)
- Antonia Garcı́a (ORCID: https://orcid.org/0000-0002-1521-8489)
- Francisco J. Rupérez (ORCID: https://orcid.org/0000-0001-6457-6234)
- Adriana Ortega‐Hernández (ORCID: https://orcid.org/0000-0002-2654-4917)
- Jana Dziaková (ORCID: https://orcid.org/0000-0001-5317-5275)
- Sofía Tesolato (ORCID: https://orcid.org/0009-0004-8495-3972)
- D. Herrero Rivera (ORCID: https://orcid.org/0000-0003-4123-3372)
- Constanza Fernández-Hernández
Institutions
- Universidad San Pablo CEU (ES)
- Universidad Complutense de Madrid (ES)
- Instituto de Salud Carlos III (ES)
- Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (ES)
- Hospital Clínico San Carlos (ES)
- Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (ES)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
- Medical Research Network (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-07-18
- DOI
- https://doi.org/10.3389/fimmu.2025.1562416
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Instituto de Salud Carlos III
- European Regional Development Fund
- Agencia Estatal de Investigación