Shared diagnostic genes and potential mechanisms between intervertebral disc degeneration and diabetes mellitus revealed by integrated transcriptomic analysis and machine learning
Our findings suggest that immune-inflammatory mechanisms, particularly involving neutrophils, underlie the comorbidity between IDD and DM. PRTN3 emerges as a promising shared diagnostic biomarker and potential therapeutic target for these conditions.
Authors
- Hao Tang
- Huadong Li
- Jianmin Wang
- Wanli Zhang (ORCID: https://orcid.org/0000-0003-0519-3684)
- Bao Song
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-07-18
- DOI
- https://doi.org/10.3389/fendo.2025.1576826
- Citations
- 1
- Primary Topic
- Musculoskeletal pain and rehabilitation
- Type
- article
- Field-Weighted Citation Impact
- 1.39