Left atrial appendage closure vs oral anticoagulation for stroke prevention in atrial fibrillation: Long-term outcomes from 4 randomized trials
In this meta-analysis of RCTs, LAAC was associated with significantly lower risks of all-cause and cardiovascular death, hemorrhagic stroke, and non-procedural clinically relevant bleeding compared with OACs, without increasing the risk of thromboembolic events or major bleeding. These findings support the consideration of LAAC as an alternative to OAC in selected patients with AF.
Authors
- Wulamiding Kaisaier (ORCID: https://orcid.org/0009-0003-4042-895X)
- Wengen Zhu (ORCID: https://orcid.org/0000-0002-1280-0158)
- Yili Chen (ORCID: https://orcid.org/0000-0001-9999-9413)
- Yugang Dong (ORCID: https://orcid.org/0000-0002-3072-5040)
- Zixuan Xu (ORCID: https://orcid.org/0009-0003-6630-1893)
- Linjuan Guo
- Gregory Y. H. Lip
Institutions
- University of Liverpool (GB)
- Sun Yat-sen University (CN)
- Liverpool Heart and Chest Hospital (GB)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Heart Rhythm
- Published
- 2025-08-05
- DOI
- https://doi.org/10.1016/j.hrthm.2025.07.051
- Citations
- 3
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 4.16
Funders
- National Natural Science Foundation of China
- Sun Yat-sen University
- Natural Science Foundation of Guangdong Province